study on tracheobronchial deposition and 2-hour retention in rabbits

Deposition of well-defined test aerosols of polystyrene particles was studied in rabbits. The deposition was estimated in a standardized part of the tracheobronchial tree following free dissection of the bronchial parts. Ten rabbits were exposed to a mixture of two test aerosols of about the same si...

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Bibliographic Details
Published inEnvironmental physiology & biochemistry Vol. 5; no. 1; pp. 1 - 7
Main Author Tomenius, L
Format Journal Article
LanguageEnglish
Published Denmark 1975
Subjects
Aerosols
animal health
animal injuries
Animals
Bronchi - analysis
Chromium Radioisotopes
Male
pesticides
Polystyrenes - analysis
Rabbits
Radioisotopes
Scandium
Time Factors
Trachea - analysis
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Summary:Deposition of well-defined test aerosols of polystyrene particles was studied in rabbits. The deposition was estimated in a standardized part of the tracheobronchial tree following free dissection of the bronchial parts. Ten rabbits were exposed to a mixture of two test aerosols of about the same size(6-7 mum) tagged with 51-Cr and 46-Sc, respectively. There were interindividual differences in tracheobronchial deposition but a correlation (r equals 0.98) between 51-Cr and 46-Sc tagged particles. Eleven rabbits were first exposed to the 46-Sc tagged aerosol and 2 hours later to the 51-Cr tagged aerosol. In this experiment there was also a correlation (r equals 0.74) between the tracheobronchial deposition of 51-Cr tagged particles and the 2-hour retention of 46-Sc tagged particles. This result together with results from an earlier study indicate that the large interindividual differences in deposition are real and are not caused by differences in exposure technique, or in the aerosols.
ISSN:0300-5429