Placentas from spontaneously hypertensive rats and control strain Wistar-Kyoto rats

Placentas from spontaneously hypertensive rats (SHR) were compared to those of control strain Wistar-Kyoto rats (WKY) at 15, 18 and 20 days of gestation using light microscopic techniques. Placental lesions similar to those in pregnant hypertensive women were absent in both strains; however, other a...

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Bibliographic Details
Published inLaboratory animal science (Chicago) Vol. 35; no. 2; p. 146
Main Authors Scott, J.N, Goecke, J.C, Ream, L.J
Format Journal Article
LanguageEnglish
Published United States 01.04.1985
Subjects
Animals
BLOOD PRESSURE
Female
HISTOLOGIA
HISTOLOGIE
HISTOLOGY
Hypertension - pathology
Hypertension - physiopathology
MONITORING
PLACENTA
Placenta - pathology
Pregnancy
PRESION SANGUINEA
PRESSION SANGUINE
RAT
RATA
RATS
Rats, Inbred SHR
Rats, Inbred WKY
STRESS
SURVEILLANCE
Time Factors
VIGILANCIA
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Summary:Placentas from spontaneously hypertensive rats (SHR) were compared to those of control strain Wistar-Kyoto rats (WKY) at 15, 18 and 20 days of gestation using light microscopic techniques. Placental lesions similar to those in pregnant hypertensive women were absent in both strains; however, other abnormalities were noted. Hemorrhage at the lateral edges of the decidua basalis appeared to be more extensive in the SHR than WKY at 15 days. At the same time, bloody vaginal discharges were noted in 18% of the SHR. Leukocytic encapsulation of 20-day placentas with viable fetuses was noted in two SHR dams but not in any WKY. It is thought that these differences may be related to the high maternal blood pressure in the SHR or to hormonal imbalance associated with the stress response in the SHR due to frequent monitoring of blood pressure.
Bibliography:L40
875249488
ISSN:0023-6764