Effects of lindane on calcium fluxes in synaptosomes

The effect of lindane on 45Ca fluxes in synaptosomes was examined to determine whether modulation of calcium regulation can explain the lindane-induced enhancement in neurotransmitter release observed in other preparations. Lindane (0.03 - 4.6 microM) enhanced calcium uptake in non-depolarizing (low...

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Published inNeurotoxicology (Park Forest South) Vol. 10; no. 1; p. 29
Main Authors Hawkinson, J.E. (University of California, Davis, CA), Shull, L.R, Joy, R.M
Format Journal Article
LanguageEnglish
Published Netherlands 1989
Subjects
Animals
CALCIO
CALCIUM
Calcium - metabolism
Calcium Radioisotopes
COMPOSE ORGANOCHLORE
COMPUESTO ORGANICO DEL CLORO
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Lindane - pharmacology
Male
NERVOUS SYSTEM
ORGANOCHLORINE COMPOUNDS
PESTICIDE
PESTICIDES
PLAGUICIDAS
Rats
Rats, Inbred Strains
SISTEMA NERVIOSO
Synaptosomes - drug effects
Synaptosomes - ultrastructure
SYSTEME NERVEUX
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Summary:The effect of lindane on 45Ca fluxes in synaptosomes was examined to determine whether modulation of calcium regulation can explain the lindane-induced enhancement in neurotransmitter release observed in other preparations. Lindane (0.03 - 4.6 microM) enhanced calcium uptake in non-depolarizing (low K+) medium: the effect was maximal at 0.1 microM lindane, which increased uptake by 15.8%. Lindane (11.5 microM) decreased calcium uptake in depolarizing (high K+) medium; lower concentrations were ineffective. In addition, lindane (9.2 microM) increased early 45Ca release from synaptosomes. However, lindane (2.4 or 5.9 microM) had no effect on calcium uptake by lysed synaptosomes in the presence or absence of mitochondrial poisons and/or ATP, indicating that lindane does not affect sub-cellular calcium storage. It is concluded that the lindane-induced changes in synaptosomal calcium flux are due to an increase in non-specific synaptic membrane permeability to calcium.
Bibliography:H01
9004886
ISSN:0161-813X
1872-9711