Inhibitory Effect of Ligularia Stenocephala on the Cancer Metastasis

Ligularia stenocephala has been used as a traditional medicine for the treatment of asthma, arthritis, jaundice, and hyperpiesia. In this study, we investigated the anti-metastatic and hypnotic effects of the methanolic extract of L. stenocephala (MLS). Gelatin zymographic analysis revealed that MLS...

Full description

Saved in:
Bibliographic Details
Published inNatural product sciences Vol. 18; no. 2
Main Authors Lee, D.K., Woosuk University, Wanju, Republic of Korea, Kim, J.K., Woosuk University, Wanju, Republic of Korea, Kim, J.S., Woosuk University, Wanju, Republic of Korea, Park, K.J., Woosuk University, Wanju, Republic of Korea, Cha, D.S., Woosuk University, Wanju, Republic of Korea, Jeon, H., Woosuk University, Wanju, Republic of Korea
Format Journal Article
LanguageEnglish
Published 01.06.2012
Subjects
Invasion
Ligularia stenocephala
Metastasis
MMP
NEOPLASMAS
NEOPLASME
NEOPLASMS
Online AccessGet more information

Cover

More Information
Summary:Ligularia stenocephala has been used as a traditional medicine for the treatment of asthma, arthritis, jaundice, and hyperpiesia. In this study, we investigated the anti-metastatic and hypnotic effects of the methanolic extract of L. stenocephala (MLS). Gelatin zymographic analysis revealed that MLS suppresses matrix metalloproteinase-2 (MMP-2) and MMP-9 activities in B16F10 cells. The gene expressions of MMPs were also down-regulated by MLS treatment in a dose-dependent manner. In addition, cancer cell invasion and migration were attenuated by MLS via suppression of NF-κB activation. The in vivo lung metastasis of B16F10 melanoma cells was also inhibited by the treatment of MLS. These findings show that MLS has anti-metastatic properties, and, therefore, it might be applicable as a valuable anti-metastatic agent.
Bibliography:T10
ISSN:1226-3907