Antisera to gonadotrophins and placental function in mice. -I. effect on polyamine content

The effect of antisera to ovine LH and ovine prolactin was studied on polyamine levels in the mouse placenta. The antisera were administered on Day 11, 12 or 13 of pregnancy and the mice were killed 24 hr later. The polyamines (spermine, spermidine and putrescine) in the placentae were estimated. Po...

Full description

Saved in:
Bibliographic Details
Published inJournal of reproduction & fertility Vol. 43; no. 2; pp. 221 - 224
Main Authors Thakur, A.N, Sheth, A.R, Purandare, T.V, Munshi, S.R, Rao, S.S
Format Journal Article
LanguageEnglish
Published England 01.05.1975
Subjects
animal science
Animals
Cross Reactions
DNA - analysis
Female
Immune Sera - pharmacology
livestock
Luteinizing Hormone - immunology
Mice
Placenta - analysis
Placenta - physiology
Polyamines - analysis
Pregnancy
Prolactin - immunology
Putrescine - analysis
RNA - analysis
Sheep - immunology
Spermidine - analysis
Spermine - analysis
zoology
Online AccessGet more information

Cover

More Information
Summary:The effect of antisera to ovine LH and ovine prolactin was studied on polyamine levels in the mouse placenta. The antisera were administered on Day 11, 12 or 13 of pregnancy and the mice were killed 24 hr later. The polyamines (spermine, spermidine and putrescine) in the placentae were estimated. Polyamine levels were reduced after treatment with anti-LH on any of the 3 days and after treatment with anti-prolactin serum on Days 11 or 12. Only the spermidine content was reduced when anti-prolactin serum was injected on Day 13 of pregnancy. Placental DNA and RNA levels paralleled those observed for polyamine content. The changes in polyamine content and nucleic acid levels indicate that these antisera to LH and prolactin interfere with placental function.
ISSN:0022-4251