Propagation of cortical spreading depression in malnourished rats: facilitatory effect of dietary protein deficiency

Adult rats, submitted from gestation to the basic regional diet (BRD) of some human populations in the northeastern region of Brazil, presented higher velocities of propagation of cortical spreading depression (SD) than well-nourished animals. This effect was also seen in rats receiving BRD during t...

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Published inBrazilian journal of medical and biological research Vol. 20; no. 5; pp. 639 - 642
Main Authors Guedes, R.C.A, Andrade, A.F.D, Cabral-Filho, J.E
Format Journal Article
LanguageEnglish
Published Brazil 1987
Subjects
Animals
cerebral cortex
Cortical Spreading Depression
Diet
Food, Fortified
malnutrition
nervous system diseases
protein deficiencies
Protein Deficiency - complications
Rats
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Summary:Adult rats, submitted from gestation to the basic regional diet (BRD) of some human populations in the northeastern region of Brazil, presented higher velocities of propagation of cortical spreading depression (SD) than well-nourished animals. This effect was also seen in rats receiving BRD during the gestation and suckling periods alone but not when this diet was administered only during adult life, suggesting that the alterations produced by BRD occur early in life. The supplementation of BRD with lipids, vitamins and minerals (but not protein) did not prevent the appearance of this facilitatory effect in the gestation + suckling group, suggesting an important effect of protein deficiency in the BRD on cortical SD.
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ISSN:0100-879X
1414-431X