Comparison of the mechanism of action of vitamin D3 and 1 alpha-OH D3 under conditions of experimental hypercalcemia

Comparison of the mechanism of action Vitamin D3 and 1 alpha-OH D3 under conditions of experimental hypercalcemia. Acta Physiol. Pol. 1979, 30 (2): 313--318. The hypercalcemic effect of supraphysiological doses of Vitamin D and 1 alpha-OH D3 were compared applying an animal model. Changes in serum c...

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Published inActa physiologica Polonica Vol. 30; no. 2; pp. 313 - 318
Main Authors Dargiel-Targonska, I, Cieslukowski, Z, Lorenc, R.S
Format Journal Article
LanguageEnglish
Published Poland 01.03.1979
Subjects
Animals
Calcium - blood
Calcium, Dietary - metabolism
Cholecalciferol - pharmacology
human nutrition
Hydroxycholecalciferols - pharmacology
Hypercalcemia - metabolism
Kinetics
nutrition education
Phosphates - metabolism
Rats
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Summary:Comparison of the mechanism of action Vitamin D3 and 1 alpha-OH D3 under conditions of experimental hypercalcemia. Acta Physiol. Pol. 1979, 30 (2): 313--318. The hypercalcemic effect of supraphysiological doses of Vitamin D and 1 alpha-OH D3 were compared applying an animal model. Changes in serum calcium of animals with normal dietary calcium supplementation and those under conditions of calcium depletion were analyzed. Dietary calcium is necessary for the hypercalcemic effect of Vitamin D, whereas in case of 1 alpha-OH D3 calcium is mobilized not only from the dietary but also from some other sources. The analysis of the hypercalcemia kinetics in the Vitamin D and 1 alpha-OH D3 treated animals indicated that the kidney 1 hydroxylase of 25 hydroxycholecalciferol is an important step in the hypercalcemia preventing mechanism.
ISSN:0044-6033