Effect of low level administration of malathion on adrenal medullary response in rats

The effect of malathion at a dose rate of 23 mg/kg (1/50th of LD-50) given intraperitoneally daily for 60 days on the activity of adrenal medulla has been investigated. Levels of adrenal catacholamines i.e adrenaline, noradrenaline, and dopamine were determined. The rise in the level of adrenaline o...

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Published inCurrent science (Bangalore) Vol. 53; no. 2; pp. 84 - 86
Main Authors Honnegowda, Uppal R.P, Garg B.D
Format Journal Article
LanguageEnglish
Published INDIAN ACADEMY OF SCIENCES 01.01.1984
Subjects
Adrenal medulla
Agriculture
Amines
Catecholamines
Dosage
Insecticides
Norepinephrine
University administration
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Summary:The effect of malathion at a dose rate of 23 mg/kg (1/50th of LD-50) given intraperitoneally daily for 60 days on the activity of adrenal medulla has been investigated. Levels of adrenal catacholamines i.e adrenaline, noradrenaline, and dopamine were determined. The rise in the level of adrenaline on 30th, 45th and 60th day were observed while noradrenaline and dopamine showed decline at 30 and 45 days. The levels of all the amines was raised above their controls on the 60th day. Changes in the contents of adrenal catecholamines indicate the hyperadrenal medullary activity. The adrenal medulla plays a part in adapting to stressful situation by releasing its catecholamine stores and later increasing the synthesis.
Bibliography:L74
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ISSN:0011-3891