Molecularly Imprinted Monolithic Stationary Phases for Liquid Chromatographic Separation of Tryptophan and N-CBZ-Phenylalanine Enantiomers

Monolithic molecularly imprinted columns were designed and prepared by an in-situ thermal-initiated copolymerization technique for rapid separation of tryptophan and N-CBZ-phenylalanine enantiomers. The influence of polymerization conditions and separation conditions on the specific molecular recogn...

Full description

Saved in:
Bibliographic Details
Published inBiotechnology and bioprocess engineering Vol. 11; no. 4; pp. 357 - 363
Main Authors Yan, Hongyuan (Inha University, Incheon, Republic of Korea), Row, K.H. (Inha University, Incheon, Republic of Korea), E-mail: rowkho@inha.ac.kr
Format Journal Article
LanguageEnglish
Published 한국생물공학회 01.08.2006
Subjects
molecular imprinted polymer
monolithic column
N-CBZ-phenylalanine
special molecular recognition
TRIPTOFANO
TRYPTOPHAN
TRYPTOPHANE
생물공학
Online AccessGet full text

Cover

More Information
Summary:Monolithic molecularly imprinted columns were designed and prepared by an in-situ thermal-initiated copolymerization technique for rapid separation of tryptophan and N-CBZ-phenylalanine enantiomers. The influence of polymerization conditions and separation conditions on the specific molecular recognition ability for enantiomers and diastereomers was investigated. The specious molecular recognition was found to be dependent on the stereo structures and the arrangement of functional groups of the imprinted molecule and the cavities in the molecularly imprinted polymer (MIP).
Bibliography:E21
2007001403
G704-000785.2006.11.4.015
ISSN:1226-8372
1976-3816
DOI:10.1007/BF03026253