A Study on the Cosmeceutical activities of Prunus Sargentii R

• Published in: Hanʼguk Ŭngyong Saengmyŏng Hwahakhoe chi Vol. 51; no. 1
• Main Authors: Park, J.M. (Daegu Haany University, Gyeongsan, Republic of Korea), Lee, J.Y. (Daegu Haany University, Gyeongsan, Republic of Korea), Park, T.S. (Daegu Haany University, Gyeongsan, Republic of Korea), Hyun, S.J. (Daegu Haany University, Gyeongsan, Republic of Korea), Kim, H.H. (Daegu Haany University, Gyeongsan, Republic of Korea), Cho, Y.J. (Sangju National University, Sangju, Republic of Korea), Kwon, O.J. (Gyeongbuk Regional Innovation Agency, Gyeongsan, Republic of Korea), Son, A.R. (Gyeongnam Provincial College in Geochang, Geochang, Republic of Korea), Kim, D.S. (Gounmi skin laser/aesthetic clinic, Daegu, Republic of Korea), An, B.J. (Daegu Haany University, Gyeongsan, Republic of Korea), E-mail: anbj@dhu.ac.kr
• Format: Journal Article
• Language: Korean
• Published: 01.03.2008
• Subjects: anti-inflammation effect; antimicrobial activity; ANTIOXIDANTES; ANTIOXIDANTS; ANTIOXYDANT; Prunus sargentii R
• ISSN: 1738-2203

Prunus sargentii R. of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, biological activity and safety test were conducted to evaluate biological activities of the extracts of P. sargentii R. as a potential pharmaceutical ingredient. The electron donating ability of its ethanol extracts at a 500 ppm level showed 92%, which was higher than that of hot water extract (59%), the superoxide dismutase (SOD)-like activity of the water extract of P. sargentii R. was about 50%, the ethanol extract of P. sargentii R. was about 40% at 1,000 ppm concentration. Xanthine oxidase inhibition by the water extract of P. sargentii R. was about 40% and that by the ethanol extract was 60% respectively at 500 ppm concentration. From the measurement on lipid oxidation, the Cu²+ chelating effect of the ethanol extract was higher than that of hot water extract. The Fe²+ chelating effect was also shown to be about 80% at a 500 ppm concentration in both hot water extract and ethanol extract. The tyrosinase inhibition effect related to skin-whitening was 26% by hot water extract and 20% by ethanol extract respectively at a 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 96% in ethanolic extract at a 500 ppm. Clear zones formed by P. sargentii R. against the human skin-resident micro-flora such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Propionibacterium acnes indicated that antimicrobial activity of the ethanol extract was higher than that of the hot water extract.