Poly(methacrylic acid) hydrogels for rumen bypass and the delivery of oral vaccines to ruminants

Poly(methacrylic acid) hydrogels were investigated for the delivery of a model antigen to the lower gastrointestinal tract of a sheep. To determine a formulation of the polymer that would deliver hydrogel without being retained in the first stomach of a ruminant, the hydrogel samples were tested by...

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Bibliographic Details
Published inACS symposium series no. 545
Main Authors Bowersock, T.L, Shalaby, W.S.W, Blevins, W.E, Levy, M, Park, K
Format Journal Article
LanguageEnglish
Published 1994
Subjects
ACIDE ORGANIQUE
ACIDOS ORGANICOS
APPAREIL DIGESTIF
COLLOIDE
COLOIDES
IMMUNISATION
INMUNIZACION
METHODE D'APPLICATION
METODOS DE APLICACION
POLIMEROS
POLYMERE
RUMIANTE
RUMINANT
SISTEMA DIGESTIVO
VACCIN
VACUNA
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Summary:Poly(methacrylic acid) hydrogels were investigated for the delivery of a model antigen to the lower gastrointestinal tract of a sheep. To determine a formulation of the polymer that would deliver hydrogel without being retained in the first stomach of a ruminant, the hydrogel samples were tested by loading them with a radiopaque material (Gastrografin) and administering them orally to sheep. The hydrogel readily bypassed the first stomach and swelled in the lower gastrointestinal tract releasing Gastrografin. This hydrogel formulation was then tested to determine whether it would reach the lower small intestinal tract to release an antigen and administered to a sheep. Chromium was detected in the sheep intestine for 96 h; the peak occurred 2-15 h after administration. The results of this study indicate that poly(methacrylic acid) hydrogels could be used to administer vaccines orally to ruminants
Bibliography:L70
L74
9505623
ISSN:0097-6156
1947-5918