Poly(methacrylic acid) hydrogels for rumen bypass and the delivery of oral vaccines to ruminants
Poly(methacrylic acid) hydrogels were investigated for the delivery of a model antigen to the lower gastrointestinal tract of a sheep. To determine a formulation of the polymer that would deliver hydrogel without being retained in the first stomach of a ruminant, the hydrogel samples were tested by...
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Published in | ACS symposium series no. 545 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
1994
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Subjects | |
Online Access | Get more information |
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Summary: | Poly(methacrylic acid) hydrogels were investigated for the delivery of a model antigen to the lower gastrointestinal tract of a sheep. To determine a formulation of the polymer that would deliver hydrogel without being retained in the first stomach of a ruminant, the hydrogel samples were tested by loading them with a radiopaque material (Gastrografin) and administering them orally to sheep. The hydrogel readily bypassed the first stomach and swelled in the lower gastrointestinal tract releasing Gastrografin. This hydrogel formulation was then tested to determine whether it would reach the lower small intestinal tract to release an antigen and administered to a sheep. Chromium was detected in the sheep intestine for 96 h; the peak occurred 2-15 h after administration. The results of this study indicate that poly(methacrylic acid) hydrogels could be used to administer vaccines orally to ruminants |
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Bibliography: | L70 L74 9505623 |
ISSN: | 0097-6156 1947-5918 |