Ractopamine hydrochloride, a phenethanolamine repartitioning agent: metabolism and tissue residues

Ractopamine HC1 (dl-4-hydroxy-alpha - [[[3-(4-hydroxyphenyl)-1-methylpropyl] -amino]methyl]benzenemethanol hydrochloride) is a phenethanolamine which promotes growth and carcass leanness when fed to swine. Residue and metabolism studies were carried out using 14C ractopamine HC1 in swine , dogs, and...

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Bibliographic Details
Published inACS symposium series no. 503
Main Authors Dalidowicz, J.E, Thomson, T.D, Babbitt, G.E
Format Journal Article
LanguageEnglish
Published 1992
Subjects
CERDO
MEDECINE VETERINAIRE
MEDICAMENT
MEDICAMENTOS
MEDICINA VETERINARIA
METABOLISME
METABOLISMO
PORCIN
PRODUCTOS
PRODUIT
RESIDU
RESIDUOS
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Summary:Ractopamine HC1 (dl-4-hydroxy-alpha - [[[3-(4-hydroxyphenyl)-1-methylpropyl] -amino]methyl]benzenemethanol hydrochloride) is a phenethanolamine which promotes growth and carcass leanness when fed to swine. Residue and metabolism studies were carried out using 14C ractopamine HC1 in swine , dogs, and rats. Swine eliminate nearly 85% of the administered ractopamine HC1 during the first day resulting in relatively low tissue residues. High performance liquid chromatography of liver and kidney extracts from 14C ractopamine HC1 treated swine, dogs, and rats showed four major metabolites of ractopamine HC1. The metabolites were characterized as three monoglucuronides and a diglucuronide of ractopamine
Bibliography:L70
9426584
ISSN:0097-6156
1947-5918