Developmental and reproductive toxicity evaluation of toluene vapor in the rat

• Published in: Reproductive toxicology (Elmsford, N.Y.) Vol. 23; no. 4; pp. 521 - 531
• Main Authors: Roberts, L.G., Nicolich, M.J., Schreiner, C.A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2007
• Subjects: Developmental toxicity; Inhalation; Rat; Teratogenicity; Toluene; Toluene vapor; Developmental toxicity; Rat; Toluene; Teratogenicity; Inhalation; Toluene vapor

The developmental toxicity of toluene was evaluated via whole body inhalation exposure, in pregnant Sprague Dawley rats exposed to toluene (99.9% pure) from gestation day (GD) 6–15 inclusive, 6 h/day, at concentrations of 0, 250, 750, 1500 and 3000 ppm (0, 938, 2812, 5625 and 11250 mg/m 3). Doses we...