Immunochemotherapy for cryptosporidiosis in immunosuppressed mouse model

Immunochemotherapy as a dual regimen (Nitazoxanide NTZ and Interferon gamma INF-gamma) and a triple one (NTZ, INF-gamma & Paromomycin PRM), administered to immunosuppressed Cryptosporidium infected mice for 10 days (4th-13th day post-infection) was evaluated during and after treatment by determi...

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Bibliographic Details
Published inJournal of the Egyptian Society of Parasitology Vol. 37; no. 3; p. 945
Main Authors Sanad, Magda M, Al-Malki, Jamila S
Format Journal Article
LanguageEnglish
Published Egypt 01.12.2007
Subjects
Animals
Antiprotozoal Agents - pharmacology
Cryptosporidiosis - drug therapy
Cryptosporidiosis - therapy
Disease Models, Animal
Drug Therapy, Combination
Humans
Immunocompromised Host
Immunotherapy
Interferon-gamma - pharmacology
Life Cycle Stages
Mice
Oocysts - drug effects
Parasite Egg Count
Paromomycin - pharmacology
Random Allocation
Thiazoles - pharmacology
Time Factors
Treatment Outcome
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Summary:Immunochemotherapy as a dual regimen (Nitazoxanide NTZ and Interferon gamma INF-gamma) and a triple one (NTZ, INF-gamma & Paromomycin PRM), administered to immunosuppressed Cryptosporidium infected mice for 10 days (4th-13th day post-infection) was evaluated during and after treatment by determination of parasite count in ileum, associated histopathological changes, oocyst count in Kinyoun's acid fast stained faecal smears, percent reduction in oocyst excretion and cure rate. Both regimens induced nearby efficacy (P > 0.05) with significant reduction in parasite count in the ileum on 7th (P < 0.01) & 14th (P < 0.001) P.I. days, partial regression of histopathological changes and reduction in oocyst count from the 2nd day post-treatment. Oocyst excretion reduction percent was reached zenith on 13th P.I day in both dual (95.76%) and triple (94.86%) regimens (P > 0.05). Complete cure was not achieved. Three days post-treatment relapse occurred in both regimens (P < 0.001) increase in oocyst count (P < 0.01) increase in parasite count in ileum, more severe histopathological changes with rapid deterioration and then, death of all remaining treated mice
ISSN:1110-0583