Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

• Published in: Cell Vol. 163; no. 6; pp. 1428 - 1443
• Main Authors: Levy, Maayan, Thaiss, Christoph A., Zeevi, David, Dohnalová, Lenka, Zilberman-Schapira, Gili, Mahdi, Jemal Ali, David, Eyal, Savidor, Alon, Korem, Tal, Herzig, Yonatan, Pevsner-Fischer, Meirav, Shapiro, Hagit, Christ, Anette, Harmelin, Alon, Halpern, Zamir, Latz, Eicke, Flavell, Richard A., Amit, Ido, Segal, Eran, Elinav, Eran
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2015
• Subjects: Animals; Antimicrobial Cationic Peptides; antimicrobial peptides; coevolution; colitis; Colitis - chemically induced; Colitis - drug therapy; Colon - immunology; Colon - metabolism; Colon - microbiology; disease susceptibility; dysbiosis; Dysbiosis - metabolism; epithelium; Germ-Free Life; histamine; homeostasis; immunomodulation; inflammasomes; Inflammasomes - immunology; Inflammatory Bowel Diseases - chemically induced; Inflammatory Bowel Diseases - drug therapy; interleukin-18; Interleukin-18 - immunology; intestines; landscapes; metabolites; metabolomics; Mice; Mice, Inbred C57BL; microbial communities; Microbiota; microorganisms; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; secretion; Signal Transduction; spermine; taurine; Taurine - administration & dosage

Host-microbiome co-evolution drives homeostasis and disease susceptibility, yet regulatory principles governing the integrated intestinal host-commensal microenvironment remain obscure. While inflammasome signaling participates in these interactions, its activators and microbiome-modulating mechanis...