Adult Stem or Progenitor Cells in Treatment for Type 1 Diabetes: Current Progress

Since the development of the Edmonton Islet Transplantation Protocol, islet transplantation has given new hope to patients with type 1 diabetes. Like solid organ transplantation, one of the biggest challenges islet transplantation faces is the shortage of available donor tissue. Finding an alternati...

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Published inCanadian Journal of Surgery Vol. 50; no. 2; pp. 137 - 142
Main Authors Liao, Yu Huan T., PhD, Verchere, C. Bruce, Warnock, Garth L
Format Journal Article
LanguageFrench
English
Published Canada CMA Impact Inc 01.04.2007
CMA Impact, Inc
Canadian Medical Association
Subjects
Adult Stem Cells - physiology
Cells
Diabetes
Diabetes Mellitus, Type 1 - therapy
Diabetes therapy
Drug therapy
Humans
Insulin
Islets of Langerhans Transplantation - trends
Medical treatment
Stem cells
Surgery
Surgical Biology for the Clinician
Tissue Engineering - trends
Transplants & implants
Type 1 diabetes
Canada
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Summary:Since the development of the Edmonton Islet Transplantation Protocol, islet transplantation has given new hope to patients with type 1 diabetes. Like solid organ transplantation, one of the biggest challenges islet transplantation faces is the shortage of available donor tissue. Finding an alternative source of islet tissue has become an increasingly important field of study. The possibility of generating insulin-secreting cells and islet tissue with adult pancreatic stem or progenitor cells has been investigated extensively. This review aims to discuss recent progress in the study of adult pancreatic stem or progenitor cells and to suggest future directions in this field.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0008-428X
1488-2310
DOI:10.1016/S0008-428X(07)50040-8