Neural stem and progenitor cells: choosing the right Shc

Neural stem cell (NSCs) are self-renewing, multipotent cells able to generate neurons, astrocytes and oligodendrocytes. Since their identification, these properties have made NSCs an attractive subject for therapeutic applications to the damaged brain. In this context, understanding the mechanisms a...

Full description

Saved in:
Bibliographic Details
Published inProgress in Brain Research Vol. 146; pp. 127 - 133
Main Authors Cataudella, Tiziana, Conti, Luciano, Cattaneo, Elena
Format Book Chapter Journal Article
LanguageEnglish
Published Netherlands Elsevier Science & Technology 2004
Subjects
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport - metabolism
Animals
Brain - cytology
Brain - metabolism
Cell Differentiation - physiology
Cell Division - physiology
Humans
Neuroglia - metabolism
Neuronal Plasticity - physiology
neuronal production
Neurons - metabolism
progenitors
self-renewal
Shc Signaling Adaptor Proteins
signaling proteins
Src Homology 2 Domain-Containing, Transforming Protein 1
Stem Cells - classification
Stem Cells - metabolism
EGFP enhanced green fluorescent protein
Shc S̄rc H̄omologue and C̄ollagene Homologue
fNC fetal Neural stem and progenitor Cells
EC embryonic stem cell
LeX Lewis X
FACS fluorescence activated cell sorting
NSCs neural stem cells
MAPc multipotent adult progenitor cell
PNA peanut agglutinin
signaling proteins
EGF epidermal growth factor
SVZ subventricular zone
HAS heat-stable antigen
self-renewal
neuronal production
FGF fibroblast growth factor
progenitors
CNS central nervous system
SSEA-1 stage-specific embryonic antigen 1
Online AccessGet full text

Cover

More Information
Summary:Neural stem cell (NSCs) are self-renewing, multipotent cells able to generate neurons, astrocytes and oligodendrocytes. Since their identification, these properties have made NSCs an attractive subject for therapeutic applications to the damaged brain. In this context, understanding the mechanisms and the molecules regulating their biological properties is important and it is focused to gain control over their proliferative and differentiative potential. Here we will discuss values and unsolved aspects of the system and the employment of potentially key molecular targets for proper control of NSCs fate.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISBN:0444514724
9780444514721
ISSN:0079-6123
1875-7855
DOI:10.1016/S0079-6123(03)46009-3