Bluetongue Virus Proteins And Particles And Their Role In Virus Entry, Assembly, And Release

This chapter summarizes the current understanding of the three-dimensional structure of BTV particles, subviral particles, and proteins and their role in the various stages of the virus life cycle. Bluetongue virus (BTV) virions (550S) are architecturally complex structures composed of seven discret...

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Bibliographic Details
Published inAdvances in Virus Research Vol. 64; pp. 69 - 123
Main Author Roy, Polly
Format Book Chapter Journal Article
LanguageEnglish
Published United States Elsevier Science & Technology 2005
Subjects
Animals
Bluetongue virus
Bluetongue virus - genetics
Bluetongue virus - physiology
Culicidae - virology
Viral Structural Proteins - genetics
Viral Structural Proteins - isolation & purification
Virion - physiology
Virology
Virus Assembly
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Summary:This chapter summarizes the current understanding of the three-dimensional structure of BTV particles, subviral particles, and proteins and their role in the various stages of the virus life cycle. Bluetongue virus (BTV) virions (550S) are architecturally complex structures composed of seven discrete proteins organized into two concentric shells, the inner and outer capsids. In addition to the seven structural proteins, three nonstructural (NS) proteins, NS1, NS2, and NS3 (and a related protein, NS3A), are synthesized in BTV-infected cells. Of these, NS3/NS3A is involved in the egress of the progeny virus. The two remaining nonstructural proteins, NS1 and NS2, are produced at high levels in the cytoplasm and are believed to be involved in virus replication, assembly, and morphogenesis.
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ISBN:012039863X
9780120398638
ISSN:0065-3527
1557-8399
DOI:10.1016/S0065-3527(05)64004-3