Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia function

• Published in: Progress in Brain Research Vol. 160; pp. 313 - 329
• Main Authors: Wickens, Jeffery R., Arbuthnott, Gordon W., Shindou, Tomomi
• Format: Book Chapter Journal Article
• Language: English
• Published: Netherlands Elsevier Science & Technology 2007
• Subjects: Action Potentials - physiology; Animals; Basal Ganglia - anatomy & histology; Basal Ganglia - physiology; competition; computation; Computer Simulation; dynamics; GABA; gamma-Aminobutyric Acid - physiology; Humans; Lateral inhibition; Neural Inhibition - physiology; Neural Networks (Computer); Neural Pathways - anatomy & histology; Neural Pathways - physiology; Neurons - physiology; spiny projection neuron; striatum; Synaptic Transmission - physiology; dynamics; spiny projection neuron; striatum; Lateral inhibition; GABA; competition; computation
• ISBN: 0444521844; 9780444521842
• ISSN: 0079-6123; 1875-7855
• DOI: 10.1016/S0079-6123(06)60018-6

This chapter outlines current interpretation of computational aspects of GABAergic circuits of the striatum. Recent hypotheses and controversial matters are reviewed. Quantitative aspects of striatal synaptology relevant to computational models are considered, with estimates of the connectivity of the spiny projection neurons and fast-spiking interneurons. Against this background, insights into the computational properties of inhibitory circuits based on analysis and simulation of simple models are discussed. The paper concludes with suggestions for further theoretical and experimental studies.