Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function: Implications for Regenerative Angiogenesis

[...]here we show that aging induces expression of Meg3. Meg3 has been shown to epigenetically regulate gene expression by interacting with Ezh2 and Jarid2 (5), and we propose that Meg3-mediated changes in epigenetic regulation of gene expression contribute to endothelial dysfunction in aging.

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 68; no. 23; pp. 2589 - 2591
Main Authors Boon, Reinier A., Hofmann, Patrick, Michalik, Katharina M., Lozano-Vidal, Noelia, Berghäuser, Denise, Fischer, Ariane, Knau, Andrea, Jaé, Nicolas, Schürmann, Christoph, Dimmeler, Stefanie
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.12.2016
Elsevier Limited
Subjects
Aging
Angiogenesis
Cardiology
Cellular Senescence - physiology
Deoxyribonucleic acid
DNA
Endothelial Cells - physiology
Epigenetics
Gene expression
Gene Silencing - physiology
Human Umbilical Vein Endothelial Cells - physiology
Humans
Neovascularization, Physiologic - physiology
Regeneration - physiology
RNA, Long Noncoding - antagonists & inhibitors
RNA, Long Noncoding - physiology
Rodents
United States > US
California
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Summary:[...]here we show that aging induces expression of Meg3. Meg3 has been shown to epigenetically regulate gene expression by interacting with Ezh2 and Jarid2 (5), and we propose that Meg3-mediated changes in epigenetic regulation of gene expression contribute to endothelial dysfunction in aging.
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ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.09.949