Developmental and reproductive toxicity evaluation of toluene vapor in the rat: I. Reproductive toxicity
The reproductive toxicity of toluene was evaluated in a 2-generation test in which male and female Sprague–Dawley rats, parental (F0) and first generation (F1), were exposed to toluene via whole body inhalation, 6 h/day, 7 days/week for 80 days premating and 15 days of mating at concentrations of 0,...
Saved in:
Published in | Reproductive toxicology (Elmsford, N.Y.) Vol. 17; no. 6; pp. 649 - 658 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.11.2003
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The reproductive toxicity of toluene was evaluated in a 2-generation test in which male and female Sprague–Dawley rats, parental (F0) and first generation (F1), were exposed to toluene via whole body inhalation, 6
h/day, 7 days/week for 80 days premating and 15 days of mating at concentrations of 0, 100, 500 and 2000
ppm (0, 375, 1875 and 7500
mg/m
3). Toluene was administered at 2000
ppm to both sexes, or to females or males only to be mated with untreated partners. Pregnant females at all dose levels were exposed from gestation day (GD) 1–20 and lactation day (LD) 5–21. At LD5, females were removed from their litters for daily exposure and returned when 6
h of exposure was completed. F1 pups selected to produce the F2 generation were treated for 80 days beginning immediately after weaning (LD21) and initially mated at a minimum of 100 days of age. F2 pups were not exposed to toluene by inhalation.
Toluene exposure did not induce adverse effects on fertility, reproductive performance, or maternal/pup behaviors during the lactation period in males and females of the parental or first generation, but did inhibit growth in F1 and F2 offspring in the 2000
ppm (both sexes treated) and 2000
ppm (females only treated) groups. Caesarean section of selected 2000
ppm (both sexes treated) dams at GD20 showed reduced fetal body weight and skeletal variations. Exposure to toluene caused decreased pup weights throughout lactation in F1 and F2 2000
ppm (both sexes treated), and 2000
ppm (females only treated) groups. Exposure at 2000
ppm to male parents only did not induce similar weight inhibition in offspring. The toluene offspring NOAEL is 500
ppm in groups in which maternal animals were exposed, and 2000
ppm for male only treated groups. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0890-6238 1873-1708 |
DOI: | 10.1016/S0890-6238(03)00106-0 |