Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma

• Published in: Brazilian journal of otorhinolaryngology Vol. 78; no. 4; pp. 59 - 65
• Main Authors: Tiveron, Rogério Costa, Freitas, Luiz Carlos Conti de, Figueiredo, David L, Serafini, Luciano N, Mamede, Rui Celso Martins, Zago, Marco A
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier Editora Ltda 01.07.2012; Elsevier
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; carcinoma; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Female; Humans; Immunohistochemistry; laryngeal neoplasms; Laryngeal Neoplasms - metabolism; Laryngeal Neoplasms - mortality; Laryngeal Neoplasms - pathology; Middle Aged; Neoplasm Proteins - analysis; Neoplasm Proteins - metabolism; Neoplasm Recurrence, Local; Neoplasm Staging; Original; S100 Calcium Binding Protein A7; S100 proteins; S100 Proteins - analysis; S100 Proteins - metabolism; Survival Analysis; S100 proteins; carcinoma; laryngeal neoplasms
• ISSN: 1808-8694; 1808-8686
• DOI: 10.1590/S1808-86942012000400012

Many studies have reported increased expression of S100 A7 (psoriasin) in neoplastic lesions. Among them are studies on breast carcinoma, bladder squamous cell carcinoma, skin tumors and oral cavity squamous cell carcinoma. The expression of S100 A7 has not been described for laryngeal cancer. Objective: This study aims to identify the expression of the calcium-binding protein S100 A7 and its correlation with squamous cell carcinomas of the larynx. Material and Methods: Specimens from 63 patients were submitted to immunohistochemistry testing with antibody S100 A7. Results were classified and compared. Results: The group with highly differentiated tumors had the highest treatment failure scores. Moderately differentiated tumors had higher treatment failure scores than poorly differentiated tumors. Higher scores were predominantly seen on stages I and II in moderately differentiated tumors, whereas score distribution was more homogeneous in advanced stage disease (III and IV). Regarding failure in treatment, the group scoring zero (3/4 complications: 75%) differed significantly from the remaining groups (13/59: 22%). Conclusions: S100 A7 marker was expressed in 93.7% of laryngeal cancer cases, with higher positive correlation rates in more differentiated tumors and significantly lower rates of treatment failure. Scores had no impact on survival rates.