Species, population and age diversity in cell resistance to adhesion of Neisseria meningitidis serogroups A, B and C

• Published in: Microbes and infection Vol. 2; no. 5; pp. 447 - 453
• Main Authors: Rumyantsev, Sergey N, Shabalov, Nikolay P, Pyasetskaya, Maria F, Rogacheva, Nina M, Bardakova, Lidia I
• Format: Journal Article
• Language: English; Russian
• Published: Lausanne Elsevier SAS 01.04.2000; Amsterdam Elsevier; Paris
• Subjects: adhesion; Adolescent; Adult; Animals; Bacterial Adhesion - immunology; biodiversity; Cattle; Child; Child, Preschool; Cricetinae; Disease Susceptibility - immunology; Equidae; Erythrocytes - immunology; Erythrocytes - microbiology; Erythrocytes - virology; Female; Guinea Pigs; Hemagglutination Tests; Horses; Humans; Immunity, Innate - immunology; individuality; Infant; Infant, Newborn; influenza; Meningitis, Meningococcal - microbiology; Mice; Middle Aged; natural immunity; Neisseria meningitidis; Neisseria meningitidis - pathogenicity; newborn's infections; Orthomyxoviridae - pathogenicity; Poultry; Pregnancy; Rabbits; Rats; receptors; Sheep; Species Specificity; Vertebrates - microbiology; Vertebrates - virology; influenza; biodiversity; receptors; natural immunity; newborn's infections; Neisseria meningitidis; adhesion; individuality
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/S1286-4579(00)00320-8

The variation of cell adherence of meningococci serogroups A, B and C and influenza viruses was investigated in 11 animal species and in humans of different age groups (1st, 2nd, 3rd and 4th weeks; 2nd-3rd months; 4th-12th months, 2nd-3rd years; and 18th-60th years of life) as well as in women during pregnancy (17th-36th weeks) and childbirth. Red blood cells of all animals tested as well as of human newborns were absolutely resistant to attachment of meningococci. In neonatal and the later periods the human cells become far differently sensitive individually to meningococcal adhesion. In contrast, the viral adhesion was characterized by different individual cell sensitivity in all age groups tested. Pregnancy and childbirth did not influence the women's cell sensitivity to adhesion of Neisseria meningitidis. Different receptors are involved in interactions of human cells with influenza viruses and meningococci. The function of meningococcal receptors on human cells develops during postnatal ontogenesis. The variations express both specific (genetic) and ontogenetic (individual) differences in natural resistance to meningococcal infection.