Mechanisms of Cardiogenesis in Cardiovascular Progenitor Cells

Self-renewing cells of the vertebrate heart have become a major subject of interest in the past decade. However, many researchers had a hard time to argue against the orthodox textbook view that defines the heart as a postmitotic organ. Once the scientific community agreed on the existence of self-r...

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Published inInternational Review of Cell and Molecular Biology Vol. 293; pp. 195 - 267
Main Authors Taubenschmid, Jasmin, Weitzer, Georg
Format Book Chapter Journal Article
LanguageEnglish
Published Netherlands Elsevier Science & Technology 2012
Subjects
Adult
Animals
Cardiogenesis
Cardiovascular progenitor cell
Cell differentiation
Cell plasticity
Embryonic Development - genetics
Embryonic Development - physiology
Heart - embryology
Humans
Models, Biological
Myocardium - cytology
Myocardium - metabolism
Organogenesis - genetics
Organogenesis - physiology
Self-renewal
Signal Transduction - genetics
Signal Transduction - physiology
Stem cell
Stem Cell Niche - genetics
Stem Cell Niche - physiology
Stem Cells - metabolism
Stem Cells - physiology
Transcriptional control
Self-renewal
Stem cell
Cardiovascular progenitor cell
Cell differentiation
Transcriptional control
Cardiogenesis
Cell plasticity
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Summary:Self-renewing cells of the vertebrate heart have become a major subject of interest in the past decade. However, many researchers had a hard time to argue against the orthodox textbook view that defines the heart as a postmitotic organ. Once the scientific community agreed on the existence of self-renewing cells in the vertebrate heart, their origin was again put on trial when transdifferentiation, dedifferentiation, and reprogramming could no longer be excluded as potential sources of self-renewal in the adult organ. Additionally, the presence of self-renewing pluripotent cells in the peripheral blood challenges the concept of tissue-specific stem and progenitor cells. Leaving these unsolved problems aside, it seems very desirable to learn about the basic biology of this unique cell type. Thus, we shall here paint a picture of cardiovascular progenitor cells including the current knowledge about their origin, basic nature, and the molecular mechanisms guiding proliferation and differentiation into somatic cells of the heart.
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ISBN:0123943043
9780123943040
ISSN:1937-6448
DOI:10.1016/B978-0-12-394304-0.00012-9