Microbial ribulose 1,5-bisphosphate carboxylase/oxygenase: a molecule for phylogenetic and enzymological investigation

Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) catalyzes the key reaction of the Calvin reductive pentose phosphate cycle and as such is responsible for life as we know it. This enzyme has been intensively studied for decades. Evidence that RubisCO phylogenies are incongruent with those d...

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Bibliographic Details
Published inFEMS Microbiology Letters Vol. 146; no. 1; pp. 13 - 22
Main Authors Watson, Gregory M.F, Tabita, F.Robert
Format Book Review
LanguageEnglish
Published Elsevier B.V 1997
Subjects
Kinetics
Molecular phylogeny
Mutagenesis
Ribulose 1,5-bisphosphate carboxylase/oxygenase
RubisCO
Structure
RubisCO
Molecular phylogeny
Kinetics
Mutagenesis
Structure
Ribulose 1,5-bisphosphate carboxylase/oxygenase
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Summary:Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) catalyzes the key reaction of the Calvin reductive pentose phosphate cycle and as such is responsible for life as we know it. This enzyme has been intensively studied for decades. Evidence that RubisCO phylogenies are incongruent with those derived from other macromolecules has been accumulating and recent discoveries have driven home this point. Here we review findings regarding RubisCO phylogeny and discuss these in the context of the important biochemical and structural features of the enzyme. The implications for the engineering of improved RubisCO enzymes are considered.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(96)00417-X