Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology

• Published in: Pharmacology, biochemistry and behavior Vol. 79; no. 4; pp. 745 - 749
• Main Authors: Morais, L.C.S.L., Quintans-Júnior, L.J., Franco, C.I.F., Almeida, J.R.G.S., Almeida, R.N.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2004; Elsevier Science
• Subjects: Animals; Antiparkinson Agents - isolation & purification; Antiparkinson Agents - therapeutic use; Behavioral psychophysiology; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Fundamental and applied biological sciences. Psychology; L-DOPA; Male; Medical sciences; Mice; Miscellaneous; Neurology; Parkinson's disease; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Plant Structures; Plumbaginaceae; Plumbago scandens; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Tremor; Tremor - chemically induced; Tremor - drug therapy; Tremorine; Tremorine - toxicity; Plumbago scandens; Mice; Parkinson's disease; Tremor; Tremorine; L-DOPA; Animal model; Nervous system diseases; Rodentia; Parkinson disease; Antiparkinson agent; Cerebral disorder; Involuntary movement; Dose activity relation; Vertebrata; Mammalia; Treatment; Mouse; Animal; Central nervous system disease; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/j.pbb.2004.10.004

Tremorine-induced tremors model is used to evaluate antiparkinsonian drugs because rest tremor is a sign that distinguishes Parkinson's disease (PD) from other diseases. The effects of crude ethanolic extract (CEE) and total acetate fraction (TAF) of Plumbago scandens were investigated at several doses. These extracts at doses of 125 and 250 mg/kg i.p. failed to reduce tremors in tremorine-treated mice. TAF showed significant effects only at a dose of 500 mg/kg. Both CEE and TAF at doses of 1000 and 2000 mg/kg i.p. suppressed the tremors in a dose-dependent fashion for 60 min. Biperiden, an anticholinergic drug, was used as standard at a dose of 3 mg/kg i.p. This study suggests that P. scandens is a plant with possible therapeutic value for PD.