D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The ac...

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Bibliographic Details
Published inBrain research Vol. 510; no. 1; p. 158
Main Authors Watson, G B, Bolanowski, M A, Baganoff, M P, Deppeler, C L, Lanthorn, T H
Format Journal Article
LanguageEnglish
Published Netherlands 26.02.1990
Subjects
Animals
Cycloserine - pharmacology
Glycine - pharmacology
Glycine - physiology
Oocytes - metabolism
Oocytes - physiology
Pyrrolidinones - pharmacology
Rats
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter - drug effects
Receptors, Neurotransmitter - physiology
RNA, Messenger
Xenopus laevis
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Summary:In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.
ISSN:0006-8993
DOI:10.1016/0006-8993(90)90745-W