The prevalence and natural history of gallstones in spinal cord injured patients

• Published in: Journal of the American College of Surgeons Vol. 189; no. 3; pp. 274 - 281
• Main Authors: Moonka, Ravi, Stiens, Steven A, Resnick, William J, McDonald, Jerome M, Eubank, William B, Dominitz, Jason A, Stelzner, Matthias G
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1999; Elsevier Science; American College of Surgeons
• Subjects: Biological and medical sciences; Chi-Square Distribution; Cholecystectomy; Cholelithiasis - diagnostic imaging; Cholelithiasis - epidemiology; Cholelithiasis - etiology; Cholelithiasis - surgery; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Incidence; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Prevalence; Risk Factors; Spinal Cord Injuries - complications; Spinal Cord Injuries - physiopathology; Ultrasonography; Human; Nervous system diseases; Biliary stone; Spinal cord; Prevalence; Central nervous system disease; Digestive diseases; Complication; Biliary tract disease; Spinal cord disease; Trauma
• ISSN: 1072-7515; 1879-1190
• DOI: 10.1016/S1072-7515(99)00143-X

Background: Individuals with a spinal cord injury are at increased risk for the development of gallstones. Because these patients cannot reliably manifest classic symptoms of biliary colic, they may be more likely to present with advanced biliary complications than patients with intact abdominal innervation. The natural history of gallstones in spinal cord injured patients has not been described. Study Design: All spinal cord injured patients seen at the Seattle Veterans Affairs Medical Center from January 1, 1993, to December 31, 1997 were included in the study. For each patient, the presence or absence of gallstones had been determined previously through screening abdominal ultrasonographic evaluations. Pertinent demographic information was obtained from medical records and patient interviews. Patients with gallstones were followed until death, cholecystectomy, or the conclusion of the study, and the annual incidence of biliary complications and patients requiring a cholecystectomy were determined. The prevalence of gallstones was established by studying the subset of patients seen at the Seattle Spinal Cord Injury Unit from January 1, 1995 to December 31, 1997. Results: Among the spinal cord injured patients, 31% either had gallstones or had undergone a cholecystectomy at some point after their injury. Increasing age, female gender, and greater severity of injury were risk factors for the formation of gallstones. Over the first 5 years after the diagnosis of gallstones, the annual incidence of cholecystectomy or biliary complications was 6.3% and 2.2%, respectively. Conclusions: Spinal cord injured patients are at increased risk for the development of gallstones. Patients with gallstones are at an increased risk for the development of biliary complications compared with neurologically intact patients, but the magnitude of this risk does not warrant prophylactic cholecystectomy.