Liver transplantation in people living with HIV: An Italian nationwide survey focusing on hepatocellular carcinoma and oncologic recurrences

• Published in: Digestive and liver disease Vol. 57; no. 8; pp. 1639 - 1645
• Main Authors: Visco-Comandini, Ubaldo, Burra, Permanent Transplant Commission, Italian Association for the Study of the Liver: Patrizia, Giannelli, Valerio, Morelli, Maria Cristina, Marrone, Giuseppe, Ponziani, Francesca Romana, Guerrini, Modena Transplant Center: Gian Piero, Di Benedetto, Fabrizio, Guaraldi, Giovanni, Puoti, Milan Niguarda Transplant Center: Massimo, Malattie Infettive, SC, De Carlis, Luciano, Trapianti, SC Chirurgia dei, Toniutto, Udine Transplant Center: Pier Luigi, Tascini, Carlo, Londero, Angela, Bellia, Milan INT Transplant Center: Valentina, Bhoori, Sherrie, Mazzaferro, Vincenzo, Carrai, Pisa Transplant Center: Paola, Ghinolfi, Davide, Caputo, Bologna Transplant Center: Francesca, Cescon, Matteo, Baroni, Ancona Transplant Center: Gianluca Svegliati, Schiadà, Laura, Lionetti, Rome POIT Transplant Center: Raffaella, D'Offizi, Gianpiero, Caioli, Alessandro, Guglielmo, Nicola, Ettorre, Giuseppe Maria, Pasulo, Bergamo Transplant Center: Luisa, Triolo, Michela, Pagano, Palermo Transplant Center: Duilio, Gruttadauria, Salvatore, Marenco, Genova Transplant Center: Simona, Carraro, Verona Transplant Center: Amedeo, Martini, Turin Transplant Center: Silvia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2025
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; de-novo; Female; HCC; HIV Infections - complications; Humans; Italy - epidemiology; Liver Neoplasms - epidemiology; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Liver Transplantation - statistics & numerical data; Male; malignancies; Middle Aged; Neoplasm Recurrence, Local - epidemiology; OLT; PLWH; recurence; Surveys and Questionnaires; Survival Rate; Italy; de-novo; malignancies; PLWH; HCC; OLT; recurence
• ISSN: 1590-8658; 1878-3562; 1878-3562
• DOI: 10.1016/j.dld.2025.02.014

Liver transplantation in people living with HIV is a well-established procedure. However, HIV infection has been suggested to be associated with higher post-transplant HCC recurrence rates and overall decreased survival, although this is based on limited real-life data. From September 2023, we conducted a survey in all Italian Liver Transplant Centers to investigate real-life data regarding numbers, listing indications, percentages of post-transplant HCC recurrence, and de novo malignancies in HIV-positive subjects. By the end of 2022, 365 subjects had received liver transplants across 13 Italian Transplant Centers. After 2009, HCC emerged as the primary indication for transplantation, accounting for 54.6 % of cases. Downstaging or bridging procedures were performed in 69.3 % of patients. Starting from 2018, the Metroticket 2.0 HCC listing criteria were utilized to prevent futile procedures. Estimated survival rates at 1, 3, and 5 years were 84.1 %, 72.9 %, and 64.4 %, respectively. During a median follow-up of 5.5 years, the HCC recurrence rate was 18.9 %, and post-transplant diagnosis of malignancies other than HCC (de novo tumors) was unexpectedly reported in 12.1 % of subjects. As reported by the survey, post-transplant HCC recurrences and survival rates at years 1 and 3 align with HIV-uninfected patients, while the 5-year survival rate is reduced.