Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon

• Published in: Journal of the American College of Surgeons Vol. 195; no. 1; pp. 33 - 40
• Main Authors: Read, Thomas E, Mutch, Matthew G, Chang, Benjamin W, McNevin, Michael S, Fleshman, James W, Birnbaum, Elisa H, Fry, Robert D, Caushaj, Philip F, Kodner, Ira J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2002; Elsevier Science
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Colectomy; Colonic Neoplasms - mortality; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Disease-Free Survival; Female; Humans; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Adenocarcinoma; Human; Relapse; Rectal disease; Surgical resection; Malignant tumor; Statistical study; Survival; Incidence; Treatment; Surgery; Rectum; Digestive diseases; Intestinal disease; Colon
• ISSN: 1072-7515; 1879-1190
• DOI: 10.1016/S1072-7515(02)01224-3

BACKGROUND: There is wide variability in reported locoregional recurrence rates after curative resection of adenocarcinoma of the intraperitoneal colon, and there is no universally accepted surgical technique regarding length of the resected specimen or extent of lymphadenectomy. The aim of this study was to determine the disease-free survival, locoregional failure, and perioperative morbidity of patients undergoing curative resection of colon adenocarcinoma. STUDY DESIGN: The records of 316 consecutive patients undergoing curative resection for primary adenocarcinoma of the intraperitoneal colon between 1990 and 1995 were reviewed. Locoregional recurrence was defined as disease at the anastomosis or in the adjacent mesentery, peritoneum, retroperitoneum, or carcinomatosis. The product-limit method (Kaplan-Meier) was used to analyze survival and tumor recurrence. RESULTS: The study population comprised 167 men and 149 women, mean age 70 ± 12 years (range 22 to 95 years). Median followup was 63 ± 25 months. Five-year disease-free survival was 84% overall. Disease-free survival paralleled tumor stage: stage I, 99% (n = 73); stage II, 87% (n = 151); stage III, 72% (n = 92). The predominant pattern of tumor recurrence was distant failure only. Overall locoregional recurrence (locoregional and locoregional plus distant) at 5 years was 4%. Locoregional recurrence paralleled tumor stage: stage I, 0%; stage II, 2%; stage III, 10%. Of the 12 patients who suffered locoregional recurrence, 9 (75%) had T4 primary tumors, N2 nodal disease, or both. Major and minor complications occurred in 93 patients (29%) including: anastomotic leak or intraabdominal abscess (n = 4, 1%); hemorrhage (n = 8, 3%); cardiac complications (n = 17, 5%); pulmonary embolism (n = 4, 1%); death (n = 2, 1%). Multivariate analysis (Cox proportional hazards) revealed that the only independent predictor of disease-free survival and locoregional control was tumor stage. CONCLUSION: Longterm survival and locoregional control can be achieved for patients with colon cancer, with low morbidity. In the absence of adjacent organ invasion and N2 nodal disease, locoregional recurrence should be a rare event. Just as for rectal cancer, the technical aspects of colectomy for colon cancer deserve renewed attention.