Anomalous effect of compression pressure on the brittle fracture tendency of α-cellulose tablets

• Published in: International journal of pharmaceutics Vol. 284; no. 1; pp. 69 - 74
• Main Authors: Uhumwangho, M.U., Okor, R.S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 13.10.2004; Elsevier
• Subjects: Biological and medical sciences; Brittle fracture index; Cellulose - chemistry; Compression pressure; Compressive Strength - drug effects; Crack resistance; Elasticity - drug effects; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Plastic and elastic compression; Plasto elasticity; Stress relief; Tablets; Brittle fracture index; Compression pressure; Plastic and elastic compression; Crack resistance; Plasto elasticity; Stress relief; Compression; Pharmaceutical technology; Brittle fracture; Cellulose; Elasticity; Pressure; Stress; Resistance; Dosage form; Tablet
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2004.07.002

The effect of varying the compression pressure on the brittle fracture tendency of α-cellulose and lactose tablets has been investigated. Tablet tensile strength, ( T), packing fraction, ( P f), and brittle fracture index (BFI) were determined at different compression pressures (0.82, 1.22 and 1.63 MPa). In another aspect of the study, α-cellulose and tapioca powders were mixed in various proportions to obtain powders of varying plastoelasticity. Their tableting characteristics T, P f and BFI were also determined at the different compression pressures. The polymer, α-cellulose displayed the characteristics of plastic compression—a low BFI but high T and P f values while lactose displayed the characteristics of elastic compression—a high BFI but low T and P f values. The degree of plastic compression decreased as the proportion of tapioca in the powder mixture increased from 0 to 50% w/w. Higher concentrations of tapioca >50% produced crumbly tablets at all compression pressures, thus indicating that tapioca is highly elastic. Increase in the compression pressure caused an increase in the BFI values of lactose tablets, 0.39–0.76 but a decrease in the BFI values of α-cellulose tablets, 0.38–0.09. This decrease became less pronounced as the plasticity of the powder mixtures decreased. The difference in the response of the tablets to the change in compression pressure relates to the difference in the plastoelasticity of the materials tested.