Inhibition of apoptosis by Elaeocarpus sylvestris in mice following whole-body exposure to ionizing radiation: Implications for radioprotectors

Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to...

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Published inFood science and biotechnology Vol. 17; no. 4
Main Authors Park, E.J. (Cheju National University, Jeju, Republic of Korea), Lee, N.H. (Cheju National University, Jeju, Republic of Korea), Ahn, G.N. (Cheju National University, Jeju, Republic of Korea), Baik, J.S. (Cheju National University, Jeju, Republic of Korea), Lee, J.H. (Cheju National University, Jeju, Republic of Korea), Hwang, K.K. (Cheju National University, Jeju, Republic of Korea), Park, J.W. (Cheju National University, Jeju, Republic of Korea), Jee, Y.H. (Cheju National University, Jeju, Republic of Korea), E-mail: yhjee@cheju.ac.kr
Format Journal Article
LanguageEnglish
Published 01.08.2008
Subjects
Elaeocarpus sylvestris
intestinal crypt cell
LINFOCITOS
LYMPHOCYTE
LYMPHOCYTES
MICE
radioprotection
RATON
SOURIS
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Summary:Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to protect radiosensitive lymphocytes and intestinal crypt cells from radiation injury induced by a single whole-body irradiation (WBI) in vivo was investigated. Our results demonstrated that in immune cells, E.S. treatment decreased the percent of tail DNA, a parameter of DNA damage, compared with levels in untreated, irradiated controls. Furthermore, apoptosis was significantly decreased in lymphocytes and intestinal crypt cells of E.S.-treated mice compared with irradiated controls. These results suggest that the E.S. extract can strengthen the radioresistance of radiosensitive lymphocytes and crypt cells by preventing apoptosis. Therefore, it was concluded that E.S. extract has the radioprotective effects in vivo through an inhibition of apoptosis.
Bibliography:2008003898
Q01
ISSN:1226-7708
2092-6456