Effect of continuous systemic infusion of D-amphetamine on the sensitivity of nigral dopamine cells to apomorphine inhibition of firing rates

Using a single-unit recording technique, sensitivity of nigral dopamine neurons to the inhibitory effect of apomorphine was examined on various days after a 7-day pretreatment with osmotic minipumps containing D-amphetamine. Continuous systemic infusion of D-amphetamine produced a short-lasting subs...

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Bibliographic Details
Published inBrain research Vol. 273; no. 2; p. 379
Main Authors Ellinwood, Jr, E H, Lee, T H
Format Journal Article
LanguageEnglish
Published Netherlands 29.08.1983
Subjects
Animals
Apomorphine - administration & dosage
Dextroamphetamine - administration & dosage
Dopamine - metabolism
Dopamine - physiology
Dose-Response Relationship, Drug
Drug Interactions
Male
Rats
Rats, Inbred Strains
Substantia Nigra - drug effects
Substantia Nigra - metabolism
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Summary:Using a single-unit recording technique, sensitivity of nigral dopamine neurons to the inhibitory effect of apomorphine was examined on various days after a 7-day pretreatment with osmotic minipumps containing D-amphetamine. Continuous systemic infusion of D-amphetamine produced a short-lasting subsensitivity of nigral neurons to apomorphine (0-2 days after D-amphetamine), followed by a supersensitivity on days 7, 8 and 9, post-amphetamine. The supersensitivity seems to persist at least for one week, suggesting one possible mechanism mediating long-term behavioral and biochemical changes following chronic high-dose amphetamine administration.
ISSN:0006-8993
DOI:10.1016/0006-8993(83)90867-3