Myelodysplastic syndrome and a nonrandom chromosomal abnormality t(1;19):: an indolent pathologic entity

The chromosomal abnormality t(1;19) is an infrequent finding in adult hematopoietic malignancies. This is only the second report of t(1;19) in association with myelodysplastic syndrome in which there was an apparent excellent response to oral cyclosporin A and a very indolent clinical course.

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Bibliographic Details
Published inCancer genetics and cytogenetics Vol. 122; no. 2; pp. 134 - 136
Main Authors Forrest, Donna L, Couban, Stephen, Nevill, Thomas J, Lee, Christine Y.L, Welch, Philip J
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.10.2000
Elsevier Science
Subjects
Adolescent
Biological and medical sciences
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 19 - genetics
Female
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Translocation, Genetic
Chromosomal aberration
Human
Malignant hemopathy
Myelodysplastic syndrome
Case study
Abnormal chromosome F19
Low malignancy
Adolescent
Abnormal chromosome A1
Cytogenetics
Abnormal chromosome
Genetics
Female
Karyotype
Chromosome translocation
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Summary:The chromosomal abnormality t(1;19) is an infrequent finding in adult hematopoietic malignancies. This is only the second report of t(1;19) in association with myelodysplastic syndrome in which there was an apparent excellent response to oral cyclosporin A and a very indolent clinical course.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(00)00294-6