Complete complementary DNA of rat tyrosine aminotransferase messenger RNA: Deduction of the primary structure of the enzyme

The primary structure of rat tyrosine aminotransferase ( l-tyrosine: 2-oxoglutarate aminotransferase; EC 2.6.1.5), a liver-specific enzyme involved in gluconeogenesis, has been deduced from the nucleotide sequence of a cloned full-length cDNA. The mRNA is 2362 nucleotides long (excluding the poly(A)...

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Published inJournal of molecular biology Vol. 184; no. 2; pp. 347 - 350
Main Authors Grange, Thierry, Guénet, Chantal, Dietrich, J.Bernard, Chasserot, Sylvette, Fromont, Micheline, Befort, Nicole, Jami, Jacques, Beck, Gisèle, Pictet, Raymond
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.07.1985
Elsevier
Subjects
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Base Sequence
Biological and medical sciences
Cloning, Molecular
DNA - genetics
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Rats
RNA, Messenger - genetics
Transferases
Tyrosine Transaminase - genetics
Vertebrata
Mammalia
Messenger RNA
Complementary DNA
Rat
Tyrosine aminotransferase
Enzyme
Transferase
Animal
Rodentia
Primary structure
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Summary:The primary structure of rat tyrosine aminotransferase ( l-tyrosine: 2-oxoglutarate aminotransferase; EC 2.6.1.5), a liver-specific enzyme involved in gluconeogenesis, has been deduced from the nucleotide sequence of a cloned full-length cDNA. The mRNA is 2362 nucleotides long (excluding the poly(A) tail) and codes for a polypeptide of 454 amino acids with a molecular weight of 50634. Unambiguous identification was obtained by comparison of this sequence with the amino acid sequences of several peptides obtained from the purified enzyme.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-2836
1089-8638
DOI:10.1016/0022-2836(85)90386-9