The Association between Exposure to Second-Hand Smoke and Disease in the Chinese Population: A Systematic Review and Meta-Analysis

• Published in: Biomedical and environmental sciences Vol. 36; no. 1; pp. 24 - 37
• Main Authors: WANG, Yu Tong, HU, Kui Ru, ZHAO, Jian, AI, Fei Ling, SHI, Yu Lin, WANG, Xue Wei, YANG, Wen Yi, WANG, Jing Xin, AI, Li Mei, WAN, Xia
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.01.2023; Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences/School of Basic Medicine,Peking Union Medical College,Beijing 100005,China
• Subjects: Asthma - epidemiology; Breast Neoplasms; Cancer; Child; China; Chinese population; Diseases of the circulatory system; Diseases of the respiratory system; East Asian People; Female; Humans; Lung Neoplasms - epidemiology; Lung Neoplasms - etiology; Meta-analysis; Second-hand smoke; Systematic review; Tobacco Smoke Pollution - adverse effects; China; Second-hand smoke; Chinese population; Diseases of the circulatory system; Systematic review; Diseases of the respiratory system; Cancer; Meta-analysis
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2023.003

To analyze the association between exposure to second-hand smoke (SHS) and 23 diseases, categorized into four classifications, among the Chinese population. We searched the literature up to June 30, 2021, and eligible studies were identified according to the PECOS format: Participants and Competitors (Chinese population), Exposure (SHS), Outcomes (Disease or Death), and Study design (Case-control or Cohort). In total, 53 studies were selected. The odds ratio (OR) for all types of cancer was 1.79 (1.56–2.05), and for individual cancers was 1.92 (1.42–2.59) for lung cancer, 1.57 (1.40–1.76) for breast cancer, 1.52 (1.12–2.05) for bladder cancer, and 1.37 (1.08–1.73) for liver cancer. The OR for circulatory system diseases was 1.92 (1.29–2.85), with a value of 2.29 (1.26–4.159) for stroke. The OR of respiratory system diseases was 1.76 (1.13–2.74), with a value of 1.82 (1.07–3.11) for childhood asthma. The original ORs were also shown for other diseases. Subgroup analyses were performed for lung and breast cancer. The ORs varied according to time period and were significant during exposure in the household; For lung cancer, the OR was significant in women. The effect of SHS exposure in China was similar to that in Western countries, but its definition and characterization require further clarification. Studies on the association between SHS exposure and certain diseases with high incidence rates are insufficient.