The association between functional HLA-G 14 bp insertion/deletion and +3142 C > G polymorphisms and susceptibility to multiple sclerosis

• Published in: Immunology letters
• Main Authors: Ben Fredj, Nadia, Sakly, Kaouthar, Bortolotti, Daria, Aissi, Mouna, Frih-Ayed, Mahbouba, Rotola, Antonella, Caselli, Elisabetta, Cura, Franscesca, Sakly, Nabil, Aouni, Mahjoub, Di Luca, Dario Di, Rizzo, Roberta
• Format: Journal Article
• Language: English
• Published: 01.12.2016
• Subjects: Allergy and Immunology; Multiple sclerosis; single nucleotide polymorphism; MHC; major histocompatibility complex; ADO; cerebrospinal fluids; UTR; HWE; Genetic polymorphism; EDSS; linkage disequilibrium; insertion/deletion; IL; human leukocyte antigen; MS; untranslated region; central nervous system; base pairs; T regulatory cells; HLA; vs; healthy volunteer blood donors; PCR; Haplotypes; INS/DEL; magnetic resonance imaging; MRI; Interleukin; soluble HLA-G; CNS; bp; Expanded Disability Status Scale; age of disease onset; SNP; CSF; Tunisia; polymerase chain reaction; OR; HLA-G antigens; CI; Tregs; versus; sHLA-G; Hardy-Weinberg equilibrium; LD; Odds ratio; confidence interval; RR-MS; Relapsing remitting Multiple sclerosis; HD
• ISSN: 0165-2478
• DOI: 10.1016/j.imlet.2016.10.006

Highlights • A significant increased frequency of the +3142 G allele was found in MS patients compared to HD. • The 14 bp DEL/ + 3142 G haplotype frequency was significantly increased in MS patients compared to HD. • An association was detected between the lower age of disease onset (ADO) in patients with the +3142 C/C genotype. • The +3142 C > G, but not the 14 bp INS/DEL, polymorphism may constitute a genetic susceptibility factor to MS in the Tunisian population.