A vector method of representation of enzymic reactions: 1. Parametric classification of types of enzymic reaction

• Published in: Process biochemistry (1991) Vol. 39; no. 7; pp. 805 - 813
• Main Author: Krupyanko, Vladimir I
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 31.03.2004
• Subjects: Activation; Correction of slope coordinates of activation; Enzymes; Inhibition; Parametric classification; Enzymes; Activation; Inhibition; Parametric classification; Correction of slope coordinates of activation
• ISSN: 1359-5113; 1873-3298
• DOI: 10.1016/S0032-9592(02)00246-7

A new “parametric” classification of the types of single-substrate enzymic reactions is proposed that includes 15 different types: seven inhibited, seven activated and one initial (uninhibited, i=0 and nonactivated, a=0). The new classification takes into account both the “parametricity” of these reactions and the mechanisms of their action. It unites all the types in an original symmetric system which vividly demonstrates the interconnection between separate (strictly definite) types of inhibited and activated enzymic reactions. The proposed classification permits the revision and some corrections to traditional “competitive” terminology as well as the application of these ideas and mathematical approaches pertinent to the calculation of reactions of enzyme inhibition for data analysis of enzyme activation.