TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons

Highlights • Three distinct subclasses of sensory neurons mediate cold responses. • Cold responses in TRPA1-expressing neurons depend on TRPA1 and not TRPM8 channels. • Cold-sensitive TRPA1 neurons express more TRPA1 than cold-insensitive TRPA1 neurons. • KV 1.2 channels attenuate cold-sensitivity o...

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Published inNeuroscience Vol. 353; pp. 76 - 86
Main Authors Memon, Tosifa, Chase, Kevin, Leavitt, Lee S, Olivera, Baldomero M, Teichert, Russell W
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 14.06.2017
Subjects
cold pain
ion channel
KV1.2
Neurology
pharmacology
TRPA1
TRPM8
K V
4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid
TRPA1
cold pain
voltage-gated potassium channel
AITC
dorsal-root ganglia
ROI
allyl isothiocyanate
fetal bovine serum
signal to noise
K V1.2
TRP
ion channel
FBS
HEPES
SNR
region of interest
pharmacology
DRG
TRPM8
transient receptor potential channel
KV1.2
KV
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Summary:Highlights • Three distinct subclasses of sensory neurons mediate cold responses. • Cold responses in TRPA1-expressing neurons depend on TRPA1 and not TRPM8 channels. • Cold-sensitive TRPA1 neurons express more TRPA1 than cold-insensitive TRPA1 neurons. • KV 1.2 channels attenuate cold-sensitivity of TRPA1-expressing neurons.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.04.001