JACC: Basic to Translational Science: The Apple That Falls Closely to the JACC Family Tree

[...]there was a need to find a home for these worthwhile papers. The FOURIER (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk) trial showed how insights gleaned from genome-wide association studies in very large patient cohorts were used to identify a n...

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 71; no. 17; pp. 1940 - 1941
Main Authors Fuster, Valentin, Mann, Douglas L
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2018
Elsevier Limited
Subjects
Cardiology
Cardiovascular disease
Clinical trials
Genome-wide association studies
Genomes
Laboratories
Medicine
Open access
Patients
Science
Therapeutic applications
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ISSN0735-1097
1558-3597
1558-3597
DOI10.1016/j.jacc.2018.03.450

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Summary:[...]there was a need to find a home for these worthwhile papers. The FOURIER (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk) trial showed how insights gleaned from genome-wide association studies in very large patient cohorts were used to identify a novel therapeutic target (3,4) that resulted in a new therapeutic approach that saved lives when added to conventional medical therapy (5). [...]given the rapid development of new cardiovascular devices and drugs, the cardiovascular generalist, specialist, or investigator of the future will need to have a firm understanding of the basis for these new therapies to stay informed about new developments in the field.
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ISSN:0735-1097
1558-3597
1558-3597
DOI:10.1016/j.jacc.2018.03.450