Nonsurgical approaches to the diagnosis and evaluation of endometriosis

An inability to make the diagnosis of endometriosis or evaluate lesion response to treatment without surgery is a clear impediment to understanding the disease and to developing new therapies. The need is particularly strong for rASRM Stage 1 or 2 disease, since higher stage (rASRM Stage 3 or 4) end...

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Bibliographic Details
Published inFertility and sterility Vol. 121; no. 2; pp. 140 - 144
Main Author Young, Steven L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2024
Subjects
BCL6
Endometriosis - diagnosis
Endometriosis - pathology
Endometriosis - therapy
Female
Humans
miRNA
Ultrasonography
BCL6
miRNA
Endometriosis diagnosis
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Summary:An inability to make the diagnosis of endometriosis or evaluate lesion response to treatment without surgery is a clear impediment to understanding the disease and to developing new therapies. The need is particularly strong for rASRM Stage 1 or 2 disease, since higher stage (rASRM Stage 3 or 4) endometriosis can often be diagnosed by ultrasound or other imaging techniques. Despite promising findings in association studies, no biomarkers or nonsurgical diagnostic or evaluation methods for Stage 1 or Stage 2 endometriosis has yet been clinically validated. Admittedly, validation is difficult, since surgery is required as a gold standard diagnostic method for comparison. This manuscript is aimed as a succinct review of what is known about nonsurgical approaches to detect and assess endometriosis, with an emphasis on Stage 1 and 2.
Bibliography:ObjectType-Article-1
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ObjectType-Review-2
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2023.12.020