DETECTION OF PRE-PLAQUE AMYLOID AGGREGATION USING FTIR

Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods...

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Bibliographic Details
Published inAlzheimer's & dementia Vol. 10; no. 4; p. P652
Main Authors Klementieva, Oxana, Engdahl, Anders, Faideau, Mathilde, Willén, Katarina Ingrid, Uvdal, Per, Gouras, Gunnar K
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.07.2014
Subjects
Basic Medicine
Clinical Medicine
Fysik
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Natural Sciences
Naturvetenskap
Neurologi
Neurology
Neurosciences
Neurovetenskaper
Physical Sciences
Subatomic Physics
Subatomär fysik
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Summary:Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1016/j.jalz.2014.05.1158