Underutilization of local salvage therapy after radiation therapy for prostate cancer

• Published in: Urologic oncology Vol. 32; no. 5; pp. 701 - 706
• Main Authors: Tran, Henry, M.D, Kwok, Jaime, Pickles, Tom, M.D, Tyldesley, Scott, M.D, Black, Peter C., M.D
• Format: Journal Article
• Language: English
• Published: United States 01.07.2014
• Subjects: Aged; Brachytherapy - utilization; British Columbia; Humans; Male; Middle Aged; Prostate-Specific Antigen - blood; Prostatic Neoplasms - radiotherapy; Prostatic Neoplasms - therapy; Radiotherapy - utilization; Registries; Retrospective Studies; Salvage Therapy - utilization; Treatment Outcome; Urology; British Columbia; Prostatic neoplasms; Salvage radical prostatectomy; Salvage brachytherapy; Brachytherapy; Radiotherapy; Cryotherapy; Salvage therapy
• ISSN: 1078-1439; 1873-2496
• DOI: 10.1016/j.urolonc.2013.12.014

Abstract Objective To evaluate the rates at which patients are offered and receive local salvage therapy (LST) after failure of primary radiotherapy for localized prostate cancer, as it is the only potentially curative treatment for localized recurrence but appears to be underutilized when compared with androgen-deprivation therapy (ADT) or observation. Materials and methods Patients with localized prostate cancer who received primary radiotherapy with curative intent between 1999 and 2000 were identified in the British Columbia Tumour Registry. Exclusion criteria included patient age >72 years, prostate-specific antigen>40 ng/ml, and clinical stage T4 at diagnosis. Data on clinicopathologic features, primary therapy, prostate-specific antigen kinetics, and salvage therapy were collected retrospectively. Radiation failure was defined as biochemical recurrence according to the Phoenix criteria or by initiation of salvage therapy. Results Of 1,782 patients treated in the study period, 1,067 met inclusion criteria. Of these, 257 failed radiation therapy. Radiation therapy failure was managed with observation (>12 mo) in 126 patients and ADT in 119. Of the observed patients, 66 subsequently received ADT. Five patients (1.8%) received LST (3 radical prostatectomy and 2 brachytherapy). Conclusions Only 2% of patients relapsing after radiation therapy for localized prostate cancer received LST. Although the benefits of LST are unproven, these findings reveal a possible underutilization of LST and indicate a need for enhanced collaboration between specialties to optimize care of this challenging cohort.