H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases

[Display omitted] During the last decades, small inorganic molecules like reactive oxygen species (ROS), nitric oxide (NO), carbon monoxide (CO) and even the highly toxic hydrogen sulfide (H2S) have been evolved as important signaling molecules that trigger crucial cellular processes by regulating t...

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Bibliographic Details
Published inPharmacological research Vol. 111; pp. 642 - 651
Main Authors Longen, Sebastian, Beck, Karl-Friedrich, Pfeilschifter, Josef
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.09.2016
Subjects
Animals
Humans
Hydrogen sulfide
Hydrogen Sulfide - metabolism
Hydropersulfide
Inflammation - metabolism
Oxidation-Reduction
Sulfhydryl Compounds - metabolism
Thiol-based redox switches
Hydrogen sulfide
Thiol-based redox switches
Hydropersulfide
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Summary:[Display omitted] During the last decades, small inorganic molecules like reactive oxygen species (ROS), nitric oxide (NO), carbon monoxide (CO) and even the highly toxic hydrogen sulfide (H2S) have been evolved as important signaling molecules that trigger crucial cellular processes by regulating the activity of kinases, phosphatases and transcription factors. These redox molecules use similar target structures and therefore, the composition of the complex ⿿redox environment⿿ determines the final outcome of signaling processes and may subsequently also affect the behavior of a cell in an inflammatory environment. Here, we discuss the role of H2S in this complex interplay with a focus on the transcription factors Nrf2 and NFκB.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2016.07.026