Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes

• Published in: FEBS letters Vol. 443; no. 3; pp. 370 - 374
• Main Authors: Cottage, Amanda, Clark, Melody, Hawker, Kelvin, Umrania, Yagnesh, Wheller, Denis, Bishop, Martin, Elgar, Greg
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 29.01.1999
• Subjects: Amino Acid Sequence; Animals; Chromosome Mapping; Cloning, Molecular; Conserved Sequence; Cosmids - genetics; Exons - genetics; Fish Proteins; Fishes - genetics; Fugu rubripes; Genomic sequence; Growth Substances - metabolism; Hepatocyte growth factor/receptor; Humans; Introns - genetics; Molecular Sequence Data; Oncogene; Oncogene Proteins, Viral - chemistry; Oncogene Proteins, Viral - genetics; Phylogeny; Plasminogen; Plasminogen - metabolism; Polymerase Chain Reaction; Proto-Oncogene Proteins c-met - chemistry; Proto-Oncogene Proteins c-met - genetics; Receptor Protein-Tyrosine Kinases - chemistry; Receptor Protein-Tyrosine Kinases - genetics; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - genetics; Sequence Alignment; Fugu rubripes; Plasminogen; Hepatocyte growth factor/receptor; Oncogene; Genomic sequence
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/S0014-5793(99)00011-3

Plasminogen related growth factors (PRGFs) and their receptors play major roles in embryogenesis, tissue regeneration and neoplasia. In order to investigate the complexity and evolution of the PRGF receptor family we have cloned and sequenced three receptors for PRGFs in the teleost fish Fugu rubripes, a model vertebrate with a compact genome. One of the receptor genes isolated encodes the orthologue of mammalian MET, whilst the other two may represent Fugu rubripes orthologues of RON and SEA. This is the first time three PRGF receptors have been identified in a single species.