Hl histones from mammalian testes: Hlt is associated with spermatogenesis in humans

Hlt is a testis-specific Hl histone variant associated with meiosis and post-meiotic stages of male germ cell development. We have now made tentative identification of Hlt in humans by a variety of criteria including electrophoretic and extractive properties. While Hlt was readily identified in extr...

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Bibliographic Details
Published inExperimental cell research Vol. 143; no. 2; pp. 451 - 454
Main Authors Seyedin, Saeid M., Kistler, W.Stephen
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1983
Subjects
Animals
Electrophoresis, Polyacrylamide Gel
Female
Histones - analysis
Histones - isolation & purification
Humans
Male
Placenta - analysis
Pregnancy
Rats
Sodium Chloride
Spermatogenesis
Testis - analysis
Trichloroacetic Acid
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Summary:Hlt is a testis-specific Hl histone variant associated with meiosis and post-meiotic stages of male germ cell development. We have now made tentative identification of Hlt in humans by a variety of criteria including electrophoretic and extractive properties. While Hlt was readily identified in extracts from normal testes, it was not detectable in extracts from aspermatogenic testes or from placenta. Identification of Hlt in humans confirms the widespread association of this unusual HI variant with spermatogenesis among mammals ranging from rodents to primates.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-4827
1090-2422
DOI:10.1016/0014-4827(83)90071-X