Effects of Aucubin Isolated from Eucommia ulmoides on UVB-induced Oxidative Stress in Human Keratinocytes HaCaT

Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, which induce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, we investigated the photoprotective effects of aucubin is...

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Bibliographic Details
Published inFood science and biotechnology Vol. 18; no. 2
Main Authors Ho, J.N., Han-Seo University, Seosan, Republic of Korea, Cho, H.Y., Korea University, Seoul, Republic of Korea, Lim, E.J., Hanyang Women's College, Seoul, Republic of Korea, Kim, H.K., Han-Seo University, Seosan, Republic of Korea
Format Journal Article
LanguageEnglish
Published 01.04.2009
Subjects
aucubin
ESTRES OXIDATIVO
matrix metalloproteinase-1 (MMP-1)
OXIDATIVE STRESS
photoaging
STRESS OXYDATIF
ultraviolet B (UVB)
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Summary:Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, which induce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, we investigated the photoprotective effects of aucubin isolated from Eucommia ulmoides. Pretreatment with aucubin markedly suppressed UVB-induced oxidative stress, which manifests as a decrease in intracellular lipid peroxidation, elevation of catalase activity, and reduced glutathione content. In addition, aucubin significantly reduced expression of matrix metalloproteinase-1 (MMP-1) protein (54%) and mRNA. Taken together, these results suggest that aucubin may offer protection against UVB-induced oxidative stress and may be used as a potential agent in prevention of UVB-induced photoaging.
Bibliography:2010003258
Q01
ISSN:1226-7708
2092-6456