Studies on the relationship between adeno-associated virus type I (AAV-1) and adenoviruses: I. Replication of AAV-1 in certain cell cultures and its effect on helper adenovirus

AAV type 1 has been shown to replicate in several species of cell cultures with the aid of certain helper adenoviruses from man, monkey, mouse, and dog. However, during the course of AAV replication the yield of the helper adenovirus was decreased. The reduction in yield of adenovirus was directly r...

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Bibliographic Details
Published inVirology (New York, N.Y.) Vol. 32; no. 1; pp. 52 - 59
Main Authors Casto, B.C., Atchison, R.W., Hammon, W.McD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1967
Subjects
Adenoviridae - metabolism
Adenoviridae - radiation effects
Adenoviruses, Canine
Culture Techniques
Cytopathogenic Effect, Viral
Helper Viruses
Microscopy, Electron
Ultraviolet Rays
Viruses - metabolism
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Summary:AAV type 1 has been shown to replicate in several species of cell cultures with the aid of certain helper adenoviruses from man, monkey, mouse, and dog. However, during the course of AAV replication the yield of the helper adenovirus was decreased. The reduction in yield of adenovirus was directly related to the quantity of AAV present and inversely- to the dose of the adenovirus challenge. The decrease in adenovirus yield was shown to be due to a reduction in the number of cells yielding virus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(67)90251-6