The effect of antibody on human prostatic acid phosphatase: Substrate utilization by enzyme or enzyme-antibody complex

Rabbit antibody to human prostatic acid phosphatase stabilizes the enzyme activity against thermal inactivation at antigen-antibody equivalents of two or greater. The pH optimum of the enzyme itself and the enzyme-antibody complex varies with different substrates. As the size of the substrate increa...

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Bibliographic Details
Published inArchives of biochemistry and biophysics Vol. 176; no. 1; pp. 154 - 158
Main Authors Foti, Andras G., Herschman, Harvey, Cooper, J.Fenimore, imFeld, Hedi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1976
Subjects
Acid Phosphatase - immunology
Acid Phosphatase - metabolism
Antigen-Antibody Reactions
Drug Stability
Hot Temperature
Humans
Hydrogen-Ion Concentration
Kinetics
Male
Prostate - enzymology
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Summary:Rabbit antibody to human prostatic acid phosphatase stabilizes the enzyme activity against thermal inactivation at antigen-antibody equivalents of two or greater. The pH optimum of the enzyme itself and the enzyme-antibody complex varies with different substrates. As the size of the substrate increases the activity of the enzyme alone decreases and antibody inhibition of enzymic activity is enhanced.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-9861
1096-0384
DOI:10.1016/0003-9861(76)90151-X