The effect of intra-CA1 agmatine microinjection on water maze learning and memory in Rat

Background: reports on amative are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 amative microinjection on water maze learning and memory has been a...

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Bibliographic Details
Published inIranian red crescent medical journal Vol. 13; no. 5; pp. 316 - 322
Main Authors Moosavi, M., Zarifkar, A., Rastegar, K., Roosta, H., Rafati, A.
Format Journal Article
LanguageEnglish
Published Dubai, United Arab Emirates Iranian Hospital 01.05.2011
Zamen Salamati Publishing
Kowsar
Subjects
Agmatine
Original
أغماتين
Learning
CA1
Rat
Memory
Water maze
Agmatine
Hippocampus
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Summary:Background: reports on amative are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 amative microinjection on water maze learning and memory has been assessed. Methods: the cannels were implanted in hippocampal CA1 regions of rats in a stereotaxic frame after general anesthesia. After one week recovery period, the animals were assessed in the reference memory version of water maze. Amative (1, 10, 100 or 200 µg / 0.5 µl) or saline were infused 20 minutes before or immediately after training. Results: Amative-treated rats did not show any significant difference neither in water maze acquisition nor in consolidation task in comparison with control and sham groups. Conclusion: Amative does not affect water maze learning and memory.
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ISSN:2074-1804
2074-1812